{
  "id": 5423,
  "name": "tirabrutinib hydrochloride",
  "cas_reg_no": "1351636-18-4",
  "smiles": "CC#CC(=O)N1CC[C@H](C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N",
  "inchikey": "SEJLPXCPMNSRAM-GOSISDBHSA-N",
  "inchi": "InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1",
  "formula": "C25H22N6O3",
  "molweight": 454.49,
  "xrefs": [
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D11070"
    },
    {
      "xref_type": "SECONDARY_CAS_RN",
      "xref": "1439901-97-9"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C4278440"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL4071161"
    },
    {
      "xref_type": "MESH_SUPPLEMENTAL_RECORD_UI",
      "xref": "C000608238"
    },
    {
      "xref_type": "INN_ID",
      "xref": "10320"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB15227"
    },
    {
      "xref_type": "UNII",
      "xref": "LXG44NDL2T"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "54755438"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "9265"
    }
  ],
  "synonyms": [
    "GS-4059",
    "ONO-4059",
    "tirabrutinib",
    "tirabrutinib hydrochloride",
    "velexbru"
  ],
  "indications": [
    {
      "omop_concept_id": 21004569,
      "omop_concept_name": "Malignant lymphoma",
      "umls_cui": "C0024299",
      "umls_semantic_type": "T191",
      "snomed_conceptid": 118600007,
      "snomed_full_name": "Malignant lymphoma"
    },
    {
      "omop_concept_id": 40249461,
      "omop_concept_name": "Primary central nervous system lymphoma",
      "umls_cui": "C0280803",
      "umls_semantic_type": "T191",
      "snomed_conceptid": 307649006,
      "snomed_full_name": "Primary central nervous system lymphoma"
    }
  ]
}