{
  "id": 5280,
  "name": "fostamatinib",
  "cas_reg_no": "901119-35-5",
  "smiles": "COC1=CC(NC2=NC(NC3=CC=C4OC(C)(C)C(=O)N(COP(O)(O)=O)C4=N3)=C(F)C=N2)=CC(OC)=C1OC",
  "inchikey": "GKDRMWXFWHEQQT-UHFFFAOYSA-N",
  "inchi": "InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)",
  "formula": "C23H26FN6O9P",
  "molweight": 580.466,
  "xrefs": [
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      "xref_type": "SECONDARY_CAS_RN",
      "xref": "914295-16-2"
    },
    {
      "xref_type": "SECONDARY_CAS_RN",
      "xref": "841290-80-0"
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    {
      "xref_type": "VANDF",
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    {
      "xref_type": "UMLSCUI",
      "xref": "C2713632"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C4730994"
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    {
      "xref_type": "PDB_CHEM_ID",
      "xref": "2RC"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2103830"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL3989516"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB12010"
    },
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D09347"
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    {
      "xref_type": "MESH_SUPPLEMENTAL_RECORD_UI",
      "xref": "C523665"
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      "xref_type": "UNII",
      "xref": "SQ8A3S5101"
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    {
      "xref_type": "PUBCHEM_CID",
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    {
      "xref_type": "PUBCHEM_CID",
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    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB07159"
    },
    {
      "xref_type": "UNII",
      "xref": "RC3A285J2G"
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    {
      "xref_type": "RXNORM",
      "xref": "2044896"
    },
    {
      "xref_type": "MMSL",
      "xref": "276522"
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    {
      "xref_type": "MMSL",
      "xref": "d08782"
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      "xref_type": "NDDF",
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    "R788",
    "R935788",
    "fostamatinib",
    "fostamatinib disodium",
    "tavalisse",
    "tavlesse"
  ],
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    {
      "atc_code": "A11HA06",
      "atc_l1_code": "A",
      "atc_l1_name": "ALIMENTARY TRACT AND METABOLISM",
      "atc_l2_code": "A11",
      "atc_l2_name": "VITAMINS",
      "atc_l3_code": "A11H",
      "atc_l3_name": "OTHER PLAIN VITAMIN PREPARATIONS",
      "atc_l4_code": "A11HA",
      "atc_l4_name": "Other plain vitamin preparations",
      "atc_substance": "pyridoxal phosphate"
    }
  ],
  "products": [
    {
      "product_id": 2428398,
      "ndc_product_code": "71332-001",
      "product_form": "TABLET",
      "product_generic_name": "FOSTAMATINIB",
      "product_name": "TAVALISSE",
      "product_route": "ORAL",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    },
    {
      "product_id": 2428399,
      "ndc_product_code": "71332-002",
      "product_form": "TABLET",
      "product_generic_name": "FOSTAMATINIB",
      "product_name": "TAVALISSE",
      "product_route": "ORAL",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 148,
      "target_name": "Adenosine receptor A3",
      "gene": "ADORA3",
      "action_type": "INHIBITOR",
      "act_source": "SCIENTIFIC LITERATURE",
      "act_type": "IC50",
      "act_comment": null,
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": NaN
    },
    {
      "target_id": 715,
      "target_name": "Tyrosine-protein kinase SYK",
      "gene": "SYK",
      "action_type": "INHIBITOR",
      "act_source": "SCIENTIFIC LITERATURE",
      "act_type": "IC50",
      "act_comment": null,
      "relation": "=",
      "moa": 1.0,
      "moa_source": "DRUG LABEL",
      "moa_source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/209299lbl.pdf",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": 2018.0
    }
  ],
  "indications": [
    {
      "omop_concept_id": 40249341,
      "omop_concept_name": "Immune thrombocytopenia",
      "umls_cui": "C0272286",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 2897005,
      "snomed_full_name": "Immune thrombocytopenia"
    }
  ]
}