{
  "id": 4988,
  "name": "deoxycholic acid",
  "cas_reg_no": "83-44-3",
  "smiles": "C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C",
  "inchikey": "KXGVEGMKQFWNSR-LLQZFEROSA-N",
  "inchi": "InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1",
  "formula": "C24H40O4",
  "molweight": 392.58,
  "xrefs": [
    {
      "xref_type": "VANDF",
      "xref": "4018928"
    },
    {
      "xref_type": "VANDF",
      "xref": "4035848"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C4305918"
    },
    {
      "xref_type": "CHEBI",
      "xref": "CHEBI:23614"
    },
    {
      "xref_type": "PDB_CHEM_ID",
      "xref": "DHO"
    },
    {
      "xref_type": "PDB_CHEM_ID",
      "xref": "DXC"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL406393"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL514674"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1208257"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL453873"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB05780"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB03619"
    },
    {
      "xref_type": "MESH_DESCRIPTOR_UI",
      "xref": "D003840"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "222528"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "610"
    },
    {
      "xref_type": "INN_ID",
      "xref": "9540"
    },
    {
      "xref_type": "UNII",
      "xref": "005990WHZZ"
    },
    {
      "xref_type": "RXNORM",
      "xref": "1367220"
    },
    {
      "xref_type": "MMSL",
      "xref": "14975"
    },
    {
      "xref_type": "MMSL",
      "xref": "234529"
    },
    {
      "xref_type": "MMSL",
      "xref": "d08364"
    },
    {
      "xref_type": "NDDF",
      "xref": "001205"
    },
    {
      "xref_type": "NDDF",
      "xref": "010267"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "781373006"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "78258003"
    }
  ],
  "synonyms": [
    "ATX-101",
    "choleic acid",
    "deoxycholate",
    "deoxycholic acid",
    "desoxycholic acid",
    "dihydroxycholanoic acid",
    "kybella",
    "sodium deoxycholate"
  ],
  "atcs": [
    {
      "atc_code": "C07BA02",
      "atc_l1_code": "C",
      "atc_l1_name": "CARDIOVASCULAR SYSTEM",
      "atc_l2_code": "C07",
      "atc_l2_name": "BETA BLOCKING AGENTS",
      "atc_l3_code": "C07B",
      "atc_l3_name": "BETA BLOCKING AGENTS AND THIAZIDES",
      "atc_l4_code": "C07BA",
      "atc_l4_name": "Beta blocking agents, non-selective, and thiazides",
      "atc_substance": "oxprenolol and thiazides"
    }
  ],
  "products": [
    {
      "product_id": 2421275,
      "ndc_product_code": "61168-101",
      "product_form": "INJECTION, SOLUTION",
      "product_generic_name": "Deoxycholic Acid",
      "product_name": "KYBELLA",
      "product_route": "SUBCUTANEOUS",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 263,
      "target_name": "fMet-Leu-Phe receptor",
      "gene": "FPR1",
      "action_type": "ANTAGONIST",
      "act_source": "IUPHAR",
      "act_type": "Ki",
      "act_comment": null,
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": NaN
    },
    {
      "target_id": 924,
      "target_name": "G-protein coupled bile acid receptor 1",
      "gene": "GPBAR1",
      "action_type": "AGONIST",
      "act_source": "IUPHAR",
      "act_type": "EC50",
      "act_comment": null,
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": NaN
    },
    {
      "target_id": 3651,
      "target_name": "Cell membrane",
      "gene": null,
      "action_type": "OTHER",
      "act_source": "DRUG LABEL",
      "act_type": null,
      "act_comment": "Mechanism of Action",
      "relation": null,
      "moa": 1.0,
      "moa_source": "DRUG LABEL",
      "moa_source_url": "http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206333Orig1s000lbl.pdf",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": 2015.0
    },
    {
      "target_id": 3864,
      "target_name": "Steroid Delta-isomerase",
      "gene": "ksi",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Kd",
      "act_comment": null,
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": NaN
    }
  ],
  "indications": [
    {
      "omop_concept_id": 40249226,
      "omop_concept_name": "Excess subcutaneous fat",
      "umls_cui": "C0424620",
      "umls_semantic_type": "T033",
      "snomed_conceptid": 248302001,
      "snomed_full_name": "Excess subcutaneous fat"
    }
  ]
}