{
  "id": 4846,
  "name": "ecallantide",
  "cas_reg_no": "460738-38-9",
  "smiles": null,
  "inchikey": null,
  "inchi": null,
  "formula": "C305H442N88O91S8",
  "molweight": 7053.9,
  "xrefs": [
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D03931"
    },
    {
      "xref_type": "VUID",
      "xref": "4029548"
    },
    {
      "xref_type": "NUI",
      "xref": "N0000180428"
    },
    {
      "xref_type": "VANDF",
      "xref": "4029548"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C4549234"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1201837"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB05311"
    },
    {
      "xref_type": "MESH_SUPPLEMENTAL_RECORD_UI",
      "xref": "C511194"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "44152182"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "6955"
    },
    {
      "xref_type": "INN_ID",
      "xref": "8476"
    },
    {
      "xref_type": "UNII",
      "xref": "5Q6TZN2HNM"
    },
    {
      "xref_type": "RXNORM",
      "xref": "658708"
    },
    {
      "xref_type": "MMSL",
      "xref": "169356"
    },
    {
      "xref_type": "MMSL",
      "xref": "26876"
    },
    {
      "xref_type": "MMSL",
      "xref": "d07521"
    },
    {
      "xref_type": "NDDF",
      "xref": "013351"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "445564003"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "445569008"
    }
  ],
  "synonyms": [
    "DX-88",
    "ecallantide",
    "kalbitor"
  ],
  "atcs": [
    {
      "atc_code": "A16AB08",
      "atc_l1_code": "A",
      "atc_l1_name": "ALIMENTARY TRACT AND METABOLISM",
      "atc_l2_code": "A16",
      "atc_l2_name": "OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS",
      "atc_l3_code": "A16A",
      "atc_l3_name": "OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS",
      "atc_l4_code": "A16AB",
      "atc_l4_name": "Enzymes",
      "atc_substance": "galsulfase"
    }
  ],
  "products": [
    {
      "product_id": 2426033,
      "ndc_product_code": "47783-101",
      "product_form": "INJECTION, SOLUTION",
      "product_generic_name": "ECALLANTIDE",
      "product_name": "KALBITOR",
      "product_route": "SUBCUTANEOUS",
      "product_marketing_status": "BLA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 1935,
      "target_name": "Plasma kallikrein",
      "gene": "KLKB1",
      "action_type": "INHIBITOR",
      "act_source": "DRUG LABEL",
      "act_type": "Ki",
      "act_comment": "Mechanism of Action",
      "relation": "=",
      "moa": 1,
      "moa_source": "DRUG LABEL",
      "moa_source_url": "http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/125277s071lbl.pdf",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": 2014
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21000780,
      "omop_concept_name": "Hereditary angioneurotic edema",
      "umls_cui": "C0019243",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 82966003,
      "snomed_full_name": "Hereditary angioneurotic edema"
    }
  ]
}