{
  "id": 4832,
  "name": "naloxegol",
  "cas_reg_no": "854601-70-0",
  "smiles": "COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@@]2(O)[C@H]3CC4=C5C(O[C@@H]1[C@@]25CCN3CC=C)=C(O)C=C4",
  "inchikey": "XNKCCCKFOQNXKV-ZRSCBOBOSA-N",
  "inchi": "InChI=1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1",
  "formula": "C34H53NO11",
  "molweight": 651.794,
  "xrefs": [
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      "xref_type": "ChEMBL_ID",
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      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2219418"
    },
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      "xref_type": "DRUGBANK_ID",
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      "xref_type": "MESH_SUPPLEMENTAL_RECORD_UI",
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      "xref_type": "IUPHAR_LIGAND_ID",
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    {
      "xref_type": "MMSL",
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    {
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  "synonyms": [
    "NKTR-118",
    "movantik",
    "moventig",
    "naloxegol",
    "naloxegol oxalate"
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  "atcs": [
    {
      "atc_code": "A03DB04",
      "atc_l1_code": "A",
      "atc_l1_name": "ALIMENTARY TRACT AND METABOLISM",
      "atc_l2_code": "A03",
      "atc_l2_name": "DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS",
      "atc_l3_code": "A03D",
      "atc_l3_name": "ANTISPASMODICS IN COMBINATION WITH ANALGESICS",
      "atc_l4_code": "A03DB",
      "atc_l4_name": "Belladonna and derivatives in combination with analgesics",
      "atc_substance": "butylscopolamine and analgesics"
    }
  ],
  "products": [
    {
      "product_id": 2410859,
      "ndc_product_code": "55700-383",
      "product_form": "TABLET, FILM COATED",
      "product_generic_name": "naloxegol oxalate",
      "product_name": "MOVANTIK",
      "product_route": "ORAL",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
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    {
      "product_id": 2417490,
      "ndc_product_code": "57841-1300",
      "product_form": "TABLET, FILM COATED",
      "product_generic_name": "naloxegol oxalate",
      "product_name": "MOVANTIK",
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      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    },
    {
      "product_id": 2417491,
      "ndc_product_code": "57841-1301",
      "product_form": "TABLET, FILM COATED",
      "product_generic_name": "naloxegol oxalate",
      "product_name": "MOVANTIK",
      "product_route": "ORAL",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 74,
      "target_name": "Mu-type opioid receptor",
      "gene": "OPRM1",
      "action_type": "ANTAGONIST",
      "act_source": "DRUG LABEL",
      "act_type": null,
      "act_comment": "Mechanism of Action",
      "relation": null,
      "moa": 1,
      "moa_source": "DRUG LABEL",
      "moa_source_url": "http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204760s000lbl.pdf",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": 2014
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21013908,
      "omop_concept_name": "Therapeutic opioid induced constipation",
      "umls_cui": "C3874358",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 136801000119102,
      "snomed_full_name": "Therapeutic opioid induced constipation"
    }
  ]
}