{
  "id": 4749,
  "name": "ospemifene",
  "cas_reg_no": "128607-22-7",
  "smiles": "OCCOC1=CC=C(C=C1)C(=C(\\CCCl)C1=CC=CC=C1)\\C1=CC=CC=C1",
  "inchikey": "LUMKNAVTFCDUIE-VHXPQNKSSA-N",
  "inchi": "InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-",
  "formula": "C24H23ClO2",
  "molweight": 378.9,
  "xrefs": [
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D08958"
    },
    {
      "xref_type": "VANDF",
      "xref": "4032347"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C0767410"
    },
    {
      "xref_type": "CHEBI",
      "xref": "CHEBI:73275"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2105395"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB04938"
    },
    {
      "xref_type": "MESH_SUPPLEMENTAL_RECORD_UI",
      "xref": "C119141"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "7349"
    },
    {
      "xref_type": "INN_ID",
      "xref": "7859"
    },
    {
      "xref_type": "UNII",
      "xref": "B0P231ILBK"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "3036505"
    },
    {
      "xref_type": "RXNORM",
      "xref": "1370971"
    },
    {
      "xref_type": "MMSL",
      "xref": "199207"
    },
    {
      "xref_type": "MMSL",
      "xref": "29311"
    },
    {
      "xref_type": "MMSL",
      "xref": "d08070"
    },
    {
      "xref_type": "NDDF",
      "xref": "014918"
    }
  ],
  "synonyms": [
    "FC-1271a",
    "ospemifene",
    "osphena",
    "senshio"
  ],
  "atcs": [
    {
      "atc_code": "C10AA01",
      "atc_l1_code": "C",
      "atc_l1_name": "CARDIOVASCULAR SYSTEM",
      "atc_l2_code": "C10",
      "atc_l2_name": "LIPID MODIFYING AGENTS",
      "atc_l3_code": "C10A",
      "atc_l3_name": "LIPID MODIFYING AGENTS, PLAIN",
      "atc_l4_code": "C10AA",
      "atc_l4_name": "HMG CoA reductase inhibitors",
      "atc_substance": "simvastatin"
    }
  ],
  "products": [
    {
      "product_id": 2422119,
      "ndc_product_code": "59630-580",
      "product_form": "TABLET, FILM COATED",
      "product_generic_name": "Ospemifene",
      "product_name": "Osphena",
      "product_route": "ORAL",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 202,
      "target_name": "Estrogen receptor",
      "gene": "ESR1",
      "action_type": "MODULATOR",
      "act_source": "WOMBAT-PK",
      "act_type": "IC50",
      "act_comment": null,
      "relation": "=",
      "moa": 1,
      "moa_source": "CHEMBL",
      "moa_source_url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2105395",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21013942,
      "omop_concept_name": "Dyspareunia",
      "umls_cui": "C1384606",
      "umls_semantic_type": "T033",
      "snomed_conceptid": 71315007,
      "snomed_full_name": "Dyspareunia"
    }
  ]
}