{
  "id": 4425,
  "name": "colistin",
  "cas_reg_no": "1066-17-7",
  "smiles": null,
  "inchikey": null,
  "inchi": null,
  "formula": "C105H198N32O26",
  "molweight": 2324.937,
  "xrefs": [
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D02138"
    },
    {
      "xref_type": "VUID",
      "xref": "4019695"
    },
    {
      "xref_type": "NUI",
      "xref": "N0000147787"
    },
    {
      "xref_type": "SECONDARY_CAS_RN",
      "xref": "1264-72-8"
    },
    {
      "xref_type": "VANDF",
      "xref": "4018640"
    },
    {
      "xref_type": "VANDF",
      "xref": "4019695"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C0009316"
    },
    {
      "xref_type": "CHEBI",
      "xref": "CHEBI:37943"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL507048"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2221249"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL499783"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2218908"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL407135"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1275798"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB00803"
    },
    {
      "xref_type": "MESH_DESCRIPTOR_UI",
      "xref": "D003091"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "5311054"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "10794"
    },
    {
      "xref_type": "INN_ID",
      "xref": "916"
    },
    {
      "xref_type": "UNII",
      "xref": "Z67X93HJG1"
    },
    {
      "xref_type": "RXNORM",
      "xref": "2709"
    },
    {
      "xref_type": "MMSL",
      "xref": "11126"
    },
    {
      "xref_type": "MMSL",
      "xref": "4496"
    },
    {
      "xref_type": "NDDF",
      "xref": "002804"
    },
    {
      "xref_type": "NDDF",
      "xref": "004903"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "23375008"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "387412007"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "73074003"
    }
  ],
  "synonyms": [
    "Polymyxin E",
    "colimycin",
    "colistin",
    "colistin sulfate",
    "colistins sulfate"
  ],
  "atcs": [
    {
      "atc_code": "A04AD05",
      "atc_l1_code": "A",
      "atc_l1_name": "ALIMENTARY TRACT AND METABOLISM",
      "atc_l2_code": "A04",
      "atc_l2_name": "ANTIEMETICS AND ANTINAUSEANTS",
      "atc_l3_code": "A04A",
      "atc_l3_name": "ANTIEMETICS AND ANTINAUSEANTS",
      "atc_l4_code": "A04AD",
      "atc_l4_name": "Other antiemetics",
      "atc_substance": "metopimazine"
    },
    {
      "atc_code": "D08AC01",
      "atc_l1_code": "D",
      "atc_l1_name": "DERMATOLOGICALS",
      "atc_l2_code": "D08",
      "atc_l2_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l3_code": "D08A",
      "atc_l3_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l4_code": "D08AC",
      "atc_l4_name": "Biguanides and amidines",
      "atc_substance": "dibrompropamidine"
    }
  ],
  "products": [
    {
      "product_id": 2383510,
      "ndc_product_code": "54868-0564",
      "product_form": "SUSPENSION",
      "product_generic_name": "colistin sulfate, neomycin sulfate, thonzonium bromide, and hydrocortisone acetate",
      "product_name": "Cortisporin-TC",
      "product_route": "AURICULAR (OTIC)",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 4
    },
    {
      "product_id": 2398661,
      "ndc_product_code": "63481-529",
      "product_form": "SUSPENSION",
      "product_generic_name": "colistin sulfate, neomycin sulfate, thonzonium bromide and hydrocortisone acetate",
      "product_name": "Cortisporin TC",
      "product_route": "AURICULAR (OTIC)",
      "product_marketing_status": "NDA",
      "product_active_ingredient_count": 4
    }
  ],
  "targets": [
    {
      "target_id": 387,
      "target_name": "Epidermal growth factor receptor",
      "gene": "EGFR",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "IC50",
      "act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 535,
      "target_name": "Tyrosine-protein kinase Fyn",
      "gene": "FYN",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "IC50",
      "act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 546,
      "target_name": "Receptor tyrosine-protein kinase erbB-2",
      "gene": "ERBB2",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "IC50",
      "act_comment": "DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr))",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 1716,
      "target_name": "Melanocortin receptor 4",
      "gene": "MC4R",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "Ki",
      "act_comment": "DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH)",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 1717,
      "target_name": "Melanocortin receptor 5",
      "gene": "MC5R",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "Ki",
      "act_comment": "DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 1718,
      "target_name": "Melanocortin receptor 3",
      "gene": "MC3R",
      "action_type": null,
      "act_source": "DRUG MATRIX",
      "act_type": "Ki",
      "act_comment": "DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)",
      "relation": "=",
      "moa": null,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21000132,
      "omop_concept_name": "Infection due to Escherichia coli",
      "umls_cui": "C0014836",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 71057007.0,
      "snomed_full_name": "Infection due to Escherichia coli"
    },
    {
      "omop_concept_id": 21000137,
      "omop_concept_name": "Pseudomonas Aeruginosa Infections",
      "umls_cui": null,
      "umls_semantic_type": null,
      "snomed_conceptid": NaN,
      "snomed_full_name": null
    },
    {
      "omop_concept_id": 21000145,
      "omop_concept_name": "Enterobacter Infection",
      "umls_cui": null,
      "umls_semantic_type": null,
      "snomed_conceptid": NaN,
      "snomed_full_name": null
    },
    {
      "omop_concept_id": 21000131,
      "omop_concept_name": "Klebsiella Infections",
      "umls_cui": null,
      "umls_semantic_type": null,
      "snomed_conceptid": NaN,
      "snomed_full_name": null
    },
    {
      "omop_concept_id": 21001368,
      "omop_concept_name": "Otitis externa",
      "umls_cui": "C0029878",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 3135009.0,
      "snomed_full_name": "Otitis externa"
    },
    {
      "omop_concept_id": 21001390,
      "omop_concept_name": "Mastoidectomy Cavity Infections",
      "umls_cui": null,
      "umls_semantic_type": null,
      "snomed_conceptid": NaN,
      "snomed_full_name": null
    }
  ]
}