{
  "id": 2733,
  "name": "trichlormethiazide",
  "cas_reg_no": "133-67-5",
  "smiles": "NS(=O)(=O)C1=CC2=C(NC(NS2(=O)=O)C(Cl)Cl)C=C1Cl",
  "inchikey": "LMJSLTNSBFUCMU-UHFFFAOYSA-N",
  "inchi": "InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)",
  "formula": "C8H8Cl3N3O4S2",
  "molweight": 380.64,
  "xrefs": [
    {
      "xref_type": "VUID",
      "xref": "4018612"
    },
    {
      "xref_type": "NUI",
      "xref": "N0000146925"
    },
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D00658"
    },
    {
      "xref_type": "VANDF",
      "xref": "4018612"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C0040899"
    },
    {
      "xref_type": "CHEBI",
      "xref": "CHEBI:9683"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1054"
    },
    {
      "xref_type": "MESH_DESCRIPTOR_UI",
      "xref": "D014237"
    },
    {
      "xref_type": "INN_ID",
      "xref": "1012"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB01021"
    },
    {
      "xref_type": "UNII",
      "xref": "Q58C92TUN0"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "5560"
    },
    {
      "xref_type": "IUPHAR_LIGAND_ID",
      "xref": "7314"
    },
    {
      "xref_type": "RXNORM",
      "xref": "10772"
    },
    {
      "xref_type": "MMSL",
      "xref": "3169"
    },
    {
      "xref_type": "MMSL",
      "xref": "5619"
    },
    {
      "xref_type": "MMSL",
      "xref": "d00646"
    },
    {
      "xref_type": "NDDF",
      "xref": "002300"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "11473005"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "409112007"
    }
  ],
  "synonyms": [
    "hydrotrichlorothiazide",
    "trichlormetazid",
    "trichlormethiazid",
    "trichlormethiazide",
    "trichloromethiazide",
    "triclormetiazide"
  ],
  "atcs": [
    {
      "atc_code": "B03AB09",
      "atc_l1_code": "B",
      "atc_l1_name": "BLOOD AND BLOOD FORMING ORGANS",
      "atc_l2_code": "B03",
      "atc_l2_name": "ANTIANEMIC PREPARATIONS",
      "atc_l3_code": "B03A",
      "atc_l3_name": "IRON PREPARATIONS",
      "atc_l4_code": "B03AB",
      "atc_l4_name": "Iron trivalent, oral preparations",
      "atc_substance": "ferric proteinsuccinylate"
    },
    {
      "atc_code": "N06AB06",
      "atc_l1_code": "N",
      "atc_l1_name": "NERVOUS SYSTEM",
      "atc_l2_code": "N06",
      "atc_l2_name": "PSYCHOANALEPTICS",
      "atc_l3_code": "N06A",
      "atc_l3_name": "ANTIDEPRESSANTS",
      "atc_l4_code": "N06AB",
      "atc_l4_name": "Selective serotonin reuptake inhibitors",
      "atc_substance": "sertraline"
    },
    {
      "atc_code": "N06AX04",
      "atc_l1_code": "N",
      "atc_l1_name": "NERVOUS SYSTEM",
      "atc_l2_code": "N06",
      "atc_l2_name": "PSYCHOANALEPTICS",
      "atc_l3_code": "N06A",
      "atc_l3_name": "ANTIDEPRESSANTS",
      "atc_l4_code": "N06AX",
      "atc_l4_name": "Other antidepressants",
      "atc_substance": "nomifensine"
    }
  ],
  "targets": [
    {
      "target_id": 161,
      "target_name": "Carbonic anhydrase 2",
      "gene": "CA2",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 185,
      "target_name": "Solute carrier family 12 member 3",
      "gene": "SLC12A3",
      "action_type": "INHIBITOR",
      "act_source": "WOMBAT-PK",
      "act_type": "A2",
      "act_comment": null,
      "relation": "=",
      "moa": 1.0,
      "moa_source": "CHEMBL",
      "moa_source_url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1054",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 213,
      "target_name": "Carbonic anhydrase 1",
      "gene": "CA1",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 220,
      "target_name": "Carbonic anhydrase 4",
      "gene": "CA4",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 319,
      "target_name": "Carbonic anhydrase 9",
      "gene": "CA9",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 330,
      "target_name": "Carbonic anhydrase 12",
      "gene": "CA12",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 398,
      "target_name": "Carbonic anhydrase 5A, mitochondrial",
      "gene": "CA5A",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 399,
      "target_name": "Carbonic anhydrase 5B, mitochondrial",
      "gene": "CA5B",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 400,
      "target_name": "Carbonic anhydrase 7",
      "gene": "CA7",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 690,
      "target_name": "Carbonic anhydrase 6",
      "gene": "CA6",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 751,
      "target_name": "Carbonic anhydrase 14",
      "gene": "CA14",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 1746,
      "target_name": "Carbonic anhydrase 13",
      "gene": "Ca13",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Ki",
      "act_comment": "Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21001432,
      "omop_concept_name": "Hypertensive disorder",
      "umls_cui": "C0020538",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 38341003,
      "snomed_full_name": "Hypertensive disorder"
    }
  ]
}