{
  "id": 2050,
  "name": "aminosalicylic acid",
  "cas_reg_no": "65-49-6",
  "smiles": "NC1=CC(O)=C(C=C1)C(O)=O",
  "inchikey": "WUBBRNOQWQTFEX-UHFFFAOYSA-N",
  "inchi": "InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)",
  "formula": "C7H7NO3",
  "molweight": 153.137,
  "xrefs": [
    {
      "xref_type": "UNII",
      "xref": "S38B9W6AXW"
    },
    {
      "xref_type": "VUID",
      "xref": "4018852"
    },
    {
      "xref_type": "NUI",
      "xref": "N0000180192"
    },
    {
      "xref_type": "KEGG_DRUG",
      "xref": "D00162"
    },
    {
      "xref_type": "SECONDARY_CAS_RN",
      "xref": "6018-19-5"
    },
    {
      "xref_type": "VANDF",
      "xref": "4018852"
    },
    {
      "xref_type": "VANDF",
      "xref": "4018919"
    },
    {
      "xref_type": "UMLSCUI",
      "xref": "C0030125"
    },
    {
      "xref_type": "CHEBI",
      "xref": "CHEBI:27565"
    },
    {
      "xref_type": "PDB_CHEM_ID",
      "xref": "BHA"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1169"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1200584"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL1200966"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2096646"
    },
    {
      "xref_type": "PUBCHEM_CID",
      "xref": "4649"
    },
    {
      "xref_type": "ChEMBL_ID",
      "xref": "CHEMBL2105983"
    },
    {
      "xref_type": "DRUGBANK_ID",
      "xref": "DB00233"
    },
    {
      "xref_type": "MESH_DESCRIPTOR_UI",
      "xref": "D010131"
    },
    {
      "xref_type": "RXNORM",
      "xref": "7833"
    },
    {
      "xref_type": "MMSL",
      "xref": "10002"
    },
    {
      "xref_type": "MMSL",
      "xref": "4176"
    },
    {
      "xref_type": "MMSL",
      "xref": "d01099"
    },
    {
      "xref_type": "MMSL",
      "xref": "d04226"
    },
    {
      "xref_type": "NDDF",
      "xref": "002845"
    },
    {
      "xref_type": "NDDF",
      "xref": "002846"
    },
    {
      "xref_type": "NDDF",
      "xref": "002847"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "20231007"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "255666002"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "417238004"
    },
    {
      "xref_type": "SNOMEDCT_US",
      "xref": "65222005"
    }
  ],
  "synonyms": [
    "4-Aminosalicylic acid",
    "4-Carboxy-3-hydroxyaniline",
    "aminosalicylate potassium",
    "aminosalicylate sodium",
    "aminosalicylic acid",
    "aminosalicylic acid resin complex",
    "apacil",
    "calcium aminosalicylate",
    "p-aminosalicylic acid",
    "para-aminosalicylic acid",
    "potassium aminosalicylate",
    "sodium aminosalicylate",
    "teebacin"
  ],
  "atcs": [
    {
      "atc_code": "D08AK01",
      "atc_l1_code": "D",
      "atc_l1_name": "DERMATOLOGICALS",
      "atc_l2_code": "D08",
      "atc_l2_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l3_code": "D08A",
      "atc_l3_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l4_code": "D08AK",
      "atc_l4_name": "Mercurial products",
      "atc_substance": "mercuric amidochloride"
    },
    {
      "atc_code": "D08AK02",
      "atc_l1_code": "D",
      "atc_l1_name": "DERMATOLOGICALS",
      "atc_l2_code": "D08",
      "atc_l2_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l3_code": "D08A",
      "atc_l3_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l4_code": "D08AK",
      "atc_l4_name": "Mercurial products",
      "atc_substance": "phenylmercuric borate"
    },
    {
      "atc_code": "D08AK03",
      "atc_l1_code": "D",
      "atc_l1_name": "DERMATOLOGICALS",
      "atc_l2_code": "D08",
      "atc_l2_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l3_code": "D08A",
      "atc_l3_name": "ANTISEPTICS AND DISINFECTANTS",
      "atc_l4_code": "D08AK",
      "atc_l4_name": "Mercurial products",
      "atc_substance": "mercuric chloride"
    }
  ],
  "products": [
    {
      "product_id": 2392638,
      "ndc_product_code": "49938-107",
      "product_form": "GRANULE, DELAYED RELEASE",
      "product_generic_name": "AMINOSALICYLIC ACID",
      "product_name": "Paser",
      "product_route": "ORAL",
      "product_marketing_status": "ANDA",
      "product_active_ingredient_count": 1
    }
  ],
  "targets": [
    {
      "target_id": 358,
      "target_name": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase",
      "gene": "folK",
      "action_type": null,
      "act_source": "WOMBAT-PK",
      "act_type": null,
      "act_comment": null,
      "relation": null,
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 424,
      "target_name": "Tyrosine-protein phosphatase non-receptor type 1",
      "gene": "PTPN1",
      "action_type": null,
      "act_source": "CHEMBL",
      "act_type": "Kd",
      "act_comment": "Dissociation constant for Protein-tyrosine phosphatase 1B",
      "relation": "=",
      "moa": NaN,
      "moa_source": null,
      "moa_source_url": null,
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    },
    {
      "target_id": 2891,
      "target_name": "Cyclooxygenase",
      "gene": "PTGS1|PTGS2",
      "action_type": "INHIBITOR",
      "act_source": "CHEMBL",
      "act_type": null,
      "act_comment": "Mechanism of Action; CHEMBL2094253; PROTEIN FAMILY",
      "relation": null,
      "moa": 1.0,
      "moa_source": "CHEMBL",
      "moa_source_url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1169",
      "ref_pmid": null,
      "ref_doi": null,
      "ref_title": null,
      "ref_year": null
    }
  ],
  "indications": [
    {
      "omop_concept_id": 21000039,
      "omop_concept_name": "Acute tuberculosis",
      "umls_cui": "C0275959",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 25629007,
      "snomed_full_name": "Acute tuberculosis"
    },
    {
      "omop_concept_id": 21000038,
      "omop_concept_name": "Pulmonary tuberculosis",
      "umls_cui": "C0041327",
      "umls_semantic_type": "T047",
      "snomed_conceptid": 154283005,
      "snomed_full_name": "Pulmonary tuberculosis"
    }
  ]
}